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[Features of the cell composition of inflammatory infiltrate in different phases of diffuse alveolar lung damage with COVID-19].

V E RodionovA M AvdalyanDmitriy KonovalovN V BoriskinI N TyurinDenis N ProtsenkoO V ZayratyantsMaxim L FilipenkoIgor P OscorbinMaksim A Koryukov
Published in: Arkhiv patologii (2022)
In the exudative phase of DAD a statistically significant predominance of PMN was revealed, which could determine the main volume of lung damage and the severity of ARDS with COVID-19. In the early stage of the proliferative phase of DAD, a statistically significant change in the composition of the inflammatory infiltrate was revealed to compare with the exudative phase: a significant decrease in the content of PMNs relative to the total number of cells in the inflammatory infiltrate; an increase in the number of lymphocytes, which is probably associated with the start of organization and repair processes. In the late stage of the proliferative phase of DAD, compared with its early stage, was revealed a statistically significant increase in the number of macrophages in ratio.
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