Chaperone patterns in vernal keratoconjunctivitis are distinctive of cell and Hsp type and are modified by inflammatory stimuli.
A LeonardiE TarriconeS CorraoM AlaibacA J CorsoB ZavanPaola VenierE Conway de MacarioA J L MacarioA Di StefanoF CappelloP BrunPublished in: Allergy (2015)
VKC conjunctiva displays distinctive quantitative patterns of Hsps as compared with healthy controls. Cultured conjunctival cells respond to cytokines and inflammatory stimuli with changes in the Hsps quantitative patterns. The data suggest that interaction between the chaperoning and the immune systems drives disease progression.
Keyphrases
- heat shock
- heat shock protein
- oxidative stress
- induced apoptosis
- high resolution
- heat stress
- single cell
- endothelial cells
- cell cycle arrest
- stem cells
- machine learning
- electronic health record
- cell therapy
- bone marrow
- big data
- cell proliferation
- mesenchymal stem cells
- endoplasmic reticulum stress
- cell death
- mass spectrometry
- artificial intelligence