Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-γ gene expression in acute experimental traumatic brain injury.
Tobias J KrämerNathalia HackTill J BrühlLutz MenzelRegina HummelEva-Verena GriemertMatthias KleinSerge C ThalTobias BoppMichael K E SchäferPublished in: Journal of neuroinflammation (2019)
The results show that the depletion of Tregs attenuates T cell brain infiltration, reactive astrogliosis, interferon-γ gene expression, and transiently motor deficits in murine acute traumatic brain injury.
Keyphrases
- traumatic brain injury
- gene expression
- regulatory t cells
- dendritic cells
- liver failure
- respiratory failure
- white matter
- resting state
- drug induced
- aortic dissection
- severe traumatic brain injury
- hepatitis b virus
- cerebral ischemia
- immune response
- multiple sclerosis
- intensive care unit
- blood brain barrier
- subarachnoid hemorrhage