JMJD3: a critical epigenetic regulator in stem cell fate.
Yuanjie DingYuanchun YaoXingmu GongQi ZhuoJinhua ChenMiao TianMaryam FarzanehPublished in: Cell communication and signaling : CCS (2021)
The Jumonji domain-containing protein-3 (JMJD3) is a histone demethylase that regulates the trimethylation of histone H3 on lysine 27 (H3K27me3). H3K27me3 is an important epigenetic event associated with transcriptional silencing. JMJD3 has been studied extensively in immune diseases, cancer, and tumor development. There is a comprehensive epigenetic transformation during the transition of embryonic stem cells (ESCs) into specialized cells or the reprogramming of somatic cells to induced pluripotent stem cells (iPSCs). Recent studies have illustrated that JMJD3 plays a major role in cell fate determination of pluripotent and multipotent stem cells (MSCs). JMJD3 has been found to enhance self-renewal ability and reduce the differentiation capacity of ESCs and MSCs. In this review, we will focus on the recent advances of JMJD3 function in stem cell fate. Video Abstract.
Keyphrases
- cell fate
- dna methylation
- induced apoptosis
- stem cells
- gene expression
- induced pluripotent stem cells
- cell cycle arrest
- mesenchymal stem cells
- embryonic stem cells
- multidrug resistant
- transcription factor
- papillary thyroid
- endoplasmic reticulum stress
- palliative care
- squamous cell carcinoma
- oxidative stress
- umbilical cord
- amino acid
- bone marrow
- young adults
- pi k akt
- lymph node metastasis
- protein protein
- solid phase extraction
- heat shock