The structural conformation of the tachykinin domain drives the anti-tumoural activity of an octopus peptide in melanoma BRAF V600E .

Javier Moral-Sanz Manuel A Fernández-Rojo Gonzalo ColmenarejoSergey KurdyukovAndreas BrustLotten RagnarssonÅsa AnderssonSabela F VilaPablo Cabezas-SainzPatrick WilhelmAna Vela-SebastiánIsabel Fernández-CarrascoYanni K Y ChinYaiza López-MancheñoTaylor B SmallwoodRichard J ClarkBryan G FryGlenn F King Grant A Ramm Paul F Alewood Richard James LewisJason P MulvennaGlen M BoyleLaura E SanchezG Gregory NeelyJohn J MilesMaria P Ikonomopoulou

Published in: British journal of pharmacology (2022)

We unravel the intrinsic anti-tumoural properties of a tachykinin peptide. This peptide mediates the selective cytotoxicity in BRAF-mutated melanoma in vitro and prevents tumour progression in vivo, providing a foundation for a therapy against melanoma.

Keyphrases

skin cancer
wild type
metastatic colorectal cancer
basal cell carcinoma
stem cells
molecular dynamics simulations
mesenchymal stem cells
replacement therapy
smoking cessation