The Impact of Process and Formulation Parameters on the Fabrication of Efavirenz Nanosuspension to Improve Drug Solubility and Dissolution.

Mahtab RashedSimin DadashzadehNoushin Bolourchian

Published in: Iranian journal of pharmaceutical research : IJPR (2022)

Optimization of different variables led to the formation of EZ-NSs with desired properties through wet milling in a very short time compared to the previous study and therefore reduced production costs. This formulation seems to be a suitable approach for solubility and dissolution enhancement of EZ and may have a great potential to improve the drug's oral bioavailability.

Keyphrases

drug delivery
adverse drug
hiv infected
emergency department
human health
risk assessment
hiv infected patients
tissue engineering