PLGA-Chitosan Encapsulated IL-10 Nanoparticles Modulate Chlamydia Inflammation in Mice.

Abebayehu N YilmaRajnish SahuPraseetha SubbarayanFrancois VillingerMamie T CoatsShree R SinghVida A Dennis

Published in: International journal of nanomedicine (2024)

Collectively, our results show the successful IL-10 encapsulation, slow release to prolong its biological half-life and reduce inflammatory cytokines IL-6 and TNF production in vitro and in mice. Our results serve as proof of concept to further explore the therapeutic prospective of encapsulated IL-10 for biomedical applications, including inflammatory diseases.

Keyphrases

drug delivery
oxidative stress
rheumatoid arthritis
high fat diet induced
metabolic syndrome
wound healing