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Discovery and implementation of a novel pathway for n-butanol production via 2-oxoglutarate.

Sofia FerreiraRui PereiraFilipe LiuPaulo VilaçaIsabel Rocha
Published in: Biotechnology for biofuels (2019)
In this work, we were able to successfully translate the computational analysis into in vivo applications, designing novel strains of E. coli able to produce n-butanol via an innovative pathway. Our results demonstrate that enumeration algorithms can broad the spectrum of butanol producing pathways. This validation encourages further research to other target compounds.
Keyphrases
  • escherichia coli
  • machine learning
  • small molecule
  • healthcare
  • deep learning
  • circulating tumor cells
  • high throughput
  • quality improvement