Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels.

Laura Rijns Lu SuKonrad MaxeinerGiulia MorgeseDavid Yuen Wah NgTanja WeilPatricia Y W Dankers

Published in: Chemical communications (Cambridge, England) (2023)

Benzene-1,3,5-tricarboxamide (BTA) glyco-monomers containing one, two or three mannose units are synthesized and formulated into differently patterned supramolecular glycopolymers through homo-assembly or co-assembly with non-functionalized BTAs. Unfortunately, no cellular activity could be detected. Excitingly, these glyco-BTA monomers could be formulated into hydrogels, paving the way for (immune) cell culture.

Keyphrases

drug delivery
hyaluronic acid
quantum dots
drug release
extracellular matrix
energy transfer
tissue engineering
water soluble
wound healing
highly efficient
molecularly imprinted
simultaneous determination