Analysis of ACE2 genetic variants in 131 Italian SARS-CoV-2-positive patients.

Antonio NovelliMichela BiancolellaPaola BorgianiDario CocciadiferroVito Luigi ColonaMaria Rosaria D'ApicePaola RoglianiSalvatore ZaffinaFrancesca LeonardisAndrea CampanaMassimiliano RaponiMassimo AndreoniSandro GrelliGiuseppe Novelli

Published in: Human genomics (2020)

Our results suggest that there is no strong evidence, in our cohort, of consistent association of ACE2 variants with COVID-19 severity. We might speculate that rare susceptibility/resistant alleles could be located in the non-coding regions of the ACE2 gene, known to play a role in regulation of the gene activity.

Keyphrases

sars cov
copy number
angiotensin converting enzyme
angiotensin ii
end stage renal disease
genome wide
coronavirus disease
newly diagnosed
chronic kidney disease
respiratory syndrome coronavirus
prognostic factors
transcription factor