Possible mechanisms involved in the anti-nociceptive effects of hydro-ethanolic leaf extract of Ziziphus abyssinica.

Eric Boakye-GyasiIsaac Tabiri HennehWonder Kofi Mensah AbotsiElvis Ofori AmeyawEric Woode

Published in: Pharmaceutical biology (2018)

EthE inhibits hypernociception induced by TNF-α, IL-1β, bradykinin and prostaglandin E2. EthE exhibited anti-nociceptive effects possibly mediated through opioidergic, adenosinergic, ATP-sensitive potassium channels and nitric oxide cyclic GMP pathways.

Keyphrases

nitric oxide
neuropathic pain
rheumatoid arthritis
hydrogen peroxide
nitric oxide synthase
spinal cord injury
escherichia coli
candida albicans