Pharmacokinetics and Bioavailability Study of Monocrotaline in Mouse Blood by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry.

Lianguo ChenBin ZhangJinlai LiuZhehua FanZiwei WengPeiwu GengLingtian Wang Guanyang Lin

Published in: BioMed research international (2018)

The results suggest that the newly standardized method for quantitative determination of MCT in whole blood is fast, reliable, specific, sensitive, and suitable for pharmacokinetic studies of MCT after intravenous or intragastric administration.

Keyphrases

liquid chromatography tandem mass spectrometry
solid phase extraction
simultaneous determination
high resolution
pulmonary hypertension
ms ms
pulmonary arterial hypertension
molecularly imprinted
high dose
tandem mass spectrometry
liquid chromatography
low dose
mass spectrometry