Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking.

Man-Xiu XieRen-Chun LaiYi-Bin XiaoXi ZhangXian-Ying CaoXiao-Yu TianAn-Nan ChenZi-Yi ChenYan CaoXiao LiXiao-Long Zhang

Published in: Military Medical Research (2024)

Our data reveal that the KIF5B/EndoA2/Piezo2 complex is essential for Piezo2 trafficking and for sustaining transmission of touch and mechanical hypersensitivity signals. EndoA2 regulates touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking in sensory neurons. Our findings identify a potential new target for the treatment of mechanical pain.

Keyphrases

neuropathic pain
spinal cord
pain management
electronic health record
deep learning
smoking cessation