Acute liver failure due to liver parenchymal infiltration with acute myelogenous leukaemia in a patient with myelodysplastic syndrome.
Lindsay A SobotkaAhmad MalliWei ChenKhalid MumtazPublished in: BMJ case reports (2018)
Liver involvement by acute leukaemia is rare and has a high mortality rate despite treatment. We report a case of a 66-year-old woman undergoing treatment for myelodysplastic syndrome with Vidaza (azacitidine) who presented with abnormal liver function tests. Despite negative serologic testing and unremarkable abdominal MRI, she continued to have significant elevation in bilirubin and international normalised ratio and worsening mental status. Liver biopsy was obtained and consistent with acute myelogenous leukaemia. The patient had rapid demise due to acute liver failure and was unable to undergo treatment.
Keyphrases
- liver failure
- hepatitis b virus
- respiratory failure
- magnetic resonance imaging
- case report
- computed tomography
- cardiovascular disease
- magnetic resonance
- acute myeloid leukemia
- type diabetes
- coronavirus disease
- sars cov
- aortic dissection
- intensive care unit
- coronary artery disease
- extracorporeal membrane oxygenation
- diffusion weighted imaging