The Synergistic Antitumor Effect of Tanshinone IIA Plus Adriamycin on Human Hepatocellular Carcinoma Xenograft in BALB/C Nude Mice and Their Influences on Cytochrome P450 CYP3A4 In Vivo.

Sui-Lin MoLi-Na ZhangYue-Yu GuMei-Gui LinJun XieYu-Ling ChenJia-Hui LiuXin-Lin Wu Sui-Lin Mo

Published in: Advances in medicine (2020)

Tan IIA in combination with ADM could improve the life quality in tumor-bearing mice and enhance the antitumor effect. The Tan IIA group increased the concentration of cytochrome P450 enzymes and activity. Combined Tan IIA with ADM could upregulate the CYP3A4 protein expression and make relevant interaction with protein PXR by virtual docking.

Keyphrases

high fat diet induced
endothelial cells
protein protein
molecular dynamics
cancer therapy
metabolic syndrome
type diabetes
insulin resistance
induced pluripotent stem cells
adipose tissue
amino acid
quality improvement
wild type
drug delivery