Neurovascular contact plays no role in trigeminal neuralgia secondary to multiple sclerosis.
Navid NooryEmil Andonov SmilkovJette Lautrup FrederiksenTone Bruvik HeinskouAnne Sofie Schott AndersenLars BendtsenStine MaarbjergPublished in: Cephalalgia : an international journal of headache (2020)
The primary cause of TN-MS is demyelination along the intrapontine trigeminal afferents. As opposed to classical trigeminal neuralgia, neurovascular contact does not play a role in the etiology of TN-MS. Microvascular decompression should generally not be offered to patients with TN-MS.The study was registered at ClinicalTrials.gov (number NCT04371575).