Functional heterogeneity of circulating T regulatory cell subsets in breast cancer patients.

Yekaterina O OstapchukYuliya V PerfilyevaElena A KustovaNatalya T UrazalievaNazgul A OmarbaevaShynar G TalaevaNikolai N Belyaev

Published in: Breast cancer (Tokyo, Japan) (2018)

Collectively, the current study shows phenotypic alterations in suppressive receptors of Treg subsets, suggesting that breast cancer patients have increased activity of N nTregs, EM nTregs and Tr1 cells; and EM nTregs and CD25+ Tr1 cells represent prospective markers for assessing disease prognosis.

Keyphrases

induced apoptosis
cell cycle arrest
single cell
peripheral blood
endoplasmic reticulum stress
oxidative stress
cell death
stem cells