Assessing the Structural and Functional Similarity of Insulin Glargine Biosimilars.
Gayatri VishwakarmaNeh NupurAnurag Singh RathorePublished in: Journal of diabetes science and technology (2021)
While an overall structural and functional similarity was observed across insulin glargine biosimilars with respect to the innovator product, low amounts of product-related variants were seen in some biosimilars and these impact product stability. The %aggregation at 14 days exhibits statistical correlation with %aggregation at 0 day and the number of months from expiry. The order of biosimilarity was denoted as Lantus®>Biosimilar 2>Biosimilar 4>Biosimilar 1>Biosimilar 3.