Antagonistic anti-LILRB1 monoclonal antibody regulates antitumor functions of natural killer cells.

Heyu ChenYuanzhi ChenMi DengSamuel JohnXun GuiAnkit KansagraWeina ChenJaehyup KimCheryl LewisGuojin WuJingjing XieLingbo ZhangRyan HuangXiaoye LiuHisashi AraseYang HuangHai YuWenxin LuoNing-Shao XiaNingyan ZhangZhiqiang AnCheng Cheng Zhang

Published in: Journal for immunotherapy of cancer (2021)

Our results indicate that blocking LILRB1 signaling on immune effector cells such as NK cells may represent a novel strategy for the development of anticancer immunotherapy.

Keyphrases

monoclonal antibody
natural killer cells
nk cells
induced apoptosis
cell cycle arrest
dendritic cells
regulatory t cells
cell death
signaling pathway
oxidative stress
pi k akt