Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity.

Mehul SutharAlberto C Moreno Kelly E ManningMaryam AzeemAjay NookaMadison EllisRenee ManaloJeffrey SwitchenkoBushra WaliJonathan KaufmanCraig HofmeisterNisha JosephSagar LonialKavita DhodapkarMadhav Dhodapkar

Published in: Research square (2023)

We characterized virus-neutralization and spike-binding antibody profiles in myeloma patients following monovalent or bivalent-SARS-CoV-2 booster vaccination. Vaccination improves the breadth of binding antibodies but not neutralization activity against current variants. Hybrid immunity and immune imprinting impact vaccine-elicited immunity.

Keyphrases

sars cov
newly diagnosed
end stage renal disease
ejection fraction
respiratory syndrome coronavirus
dna binding
chronic kidney disease
binding protein
peritoneal dialysis
prognostic factors
copy number
gene expression
dna methylation
dengue virus
zika virus
genome wide