Chiral Discrimination of P-glycoprotein in Parturient Women: Effect of Fluoxetine on Maternal-Fetal Fexofenadine Pharmacokinetics.
Leonardo PintoFernanda de Lima MoreiraGlauco Henrique Balthazar NardottoRicardo de Carvalho CavalliElaine Christine Dantas MoisésGeraldo DuarteVera Lucia LanchotePublished in: Pharmaceutical research (2020)
A single oral dose of 40 mg fluoxetine inhibited the intestinal P-gp mediated transport of S-(-)-fexofenadine to a greater extent than R-(+)-fexofenadine in parturient women. However, the placental P-gp did not discriminate fexofenadine enantiomers and was not inhibited by fluoxetine.