LIMS1 risk genotype and T cell-mediated rejection in kidney transplant recipients.
Yasar CaliskanGonca KarahanSebahat Usta AkgulSafak MiriogluYasemin OzlukHalil YaziciErol DemirAhmet B DirimAydin TurkmenJohn EdwardsFatma Oguz SavranMehmet S SeverKrzysztof KirylukAli GharaviKrista L LentinePublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2022)
Our study demonstrates that recipient LIMS1 risk genotype is associated with an increased risk of TCMR after kidney transplantation, confirming the role of the LIMS1 locus in allograft rejection. These findings may have clinical implications for the prediction and clinical management of kidney transplant rejection by pretransplant genetic testing of recipients and donors for LIMS1 risk genotype.
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