Increased Mutagen Sensitivity and DNA Damage in Pulmonary Arterial Hypertension.
Chiara FedericiKylie Marie DrakeChristina M RigelskyLauren N McNellySirena L MeadeSuzy A A ComhairSerpil C ErzurumMicheala A AldredPublished in: American journal of respiratory and critical care medicine (2015)
Levels of baseline and mutagen-induced DNA damage are intrinsically higher in PAH cells. Similar results in PBMC from unaffected relatives suggest this may be a genetically determined trait that predates disease onset and may act as a risk factor contributing to lung vascular remodeling following endothelial cell injury. Further studies are required to fully characterize mutagen sensitivity, which could have important implications for clinical management.
Keyphrases
- dna damage
- pulmonary arterial hypertension
- high glucose
- oxidative stress
- induced apoptosis
- pulmonary artery
- pulmonary hypertension
- dna repair
- endothelial cells
- diabetic rats
- risk factors
- cell cycle arrest
- genome wide
- endoplasmic reticulum stress
- gene expression
- drug induced
- coronary artery
- cell proliferation
- pi k akt
- vascular endothelial growth factor