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Increased Mutagen Sensitivity and DNA Damage in Pulmonary Arterial Hypertension.

Chiara FedericiKylie Marie DrakeChristina M RigelskyLauren N McNellySirena L MeadeSuzy A A ComhairSerpil C ErzurumMicheala A Aldred
Published in: American journal of respiratory and critical care medicine (2015)
Levels of baseline and mutagen-induced DNA damage are intrinsically higher in PAH cells. Similar results in PBMC from unaffected relatives suggest this may be a genetically determined trait that predates disease onset and may act as a risk factor contributing to lung vascular remodeling following endothelial cell injury. Further studies are required to fully characterize mutagen sensitivity, which could have important implications for clinical management.
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