CircZSWIM6 mediates dysregulation of ECM and energy homeostasis in ageing chondrocytes through RPS14 post-translational modification.

Zhe GongKefan WangJunxin ChenJinjin ZhuZhenhua FengChenxin SongZheyuan ZhangHaoming WangShunwu FanShuying ShenXiang-Qian Fang

Published in: Clinical and translational medicine (2023)

Our results revealed a significant role of CircZSWIM6 in age-related OA by regulating ECM metabolism and AMPK-associated energy metabolism. We highlight the CircZSWIM6-RPS14-PCK1-AMPK axis is a potential biomarker for OA.

Keyphrases

extracellular matrix
skeletal muscle
knee osteoarthritis
protein kinase