What Antibiotic Exposures Are Required to Suppress the Emergence of Resistance for Gram-Negative Bacteria? A Systematic Review.
Chandra Datta SumiAaron J HeffernanJeffrey LipmanJason Alexander RobertsFekade Bruck SimePublished in: Clinical pharmacokinetics (2020)
The benefits of implementing such high PK/PD targets must be balanced with the potential risks of antibiotic-associated toxicity.