Cross-reactive antibody-dependent cellular cytotoxicity antibodies are increased by recent infection in a household study of influenza transmission.

Sophie A ValkenburgVicky J FangNancy Hiu Lan LeungDaniel Kw ChuDennis Km IpRanawaka Apm PereraYizhuo WangAthena Py LiJs Malik PeirisBenjamin J CowlingLeo Lm Poon

Published in: Clinical & translational immunology (2019)

Overall, ADCC responses are a protective correlate against influenza virus infection that should be considered in future vaccine development and evaluation.Influenza-specific ADCC responses are elevated in uninfected subjects, associated with reduced symptoms and boosted by recent infection, whilst HA stem and NA IgG are also elevated in uninfected participants irrespective of ADCC function.

Keyphrases

hiv infected
antiretroviral therapy
current status
depressive symptoms
sleep quality