Deletion of both Dectin-1 and Dectin-2 affects the bacterial but not fungal gut microbiota and susceptibility to colitis in mice.
Yazhou WangMadeleine SpatzGregory Da CostaChloé MichaudelAlexia LapiereCamille DanneAllison AgusMarie-Laure MichelMihai G NeteaPhilippe LangellaHarry SokolMathias L RichardPublished in: Microbiome (2022)
Deletion of both the Dectin-1 and Dectin-2 receptors triggered a global shift in the microbial gut environment, affecting, surprisingly, mainly the bacterial population and driving protective effects in colitis. Members of the Lachnospiraceae family seem to play a central role in this protection. These findings provide new insights into the role of the Dectin receptors, which have been described to date as affecting only the fungal population, in intestinal physiopathology and in IBD. Video Abstract.