Low frataxin mRNA expression is associated with inflammation and oxidative stress in patients with type 2 diabetes.
Etiane TatschJosé A M De CarvalhoYãnaí S BollickThiago DuarteMarta M M F DuarteRodrigo A VaucherMelissa O PremaorFabio V ComimRafael Noal MorescoPublished in: Diabetes/metabolism research and reviews (2019)
Our findings showed that T2D patients with low frataxin mRNA levels showed a high degree of inflammation and oxidative stress. It is speculated that frataxin deficiency in T2D patients can contribute to the imbalance in mitochondrial iron homeostasis leading to the acceleration of oxidative stress and inflammation.