Apolipoprotein E favours the blunting by high-fat diet of prostacyclin receptor activation in the mouse aorta.
Yanhua ChengPaul M VanhoutteSusan W S LeungPublished in: British journal of pharmacology (2018)
Iloprost induced an endothelium-dependent relaxation in the aorta of young healthy mice which involved both the cGMP and cAMP pathways. This response was blunted by prolonged exposure to a high-fat diet. Apolipoprotein E deletion potentiated relaxations to IP receptor activation, independently of age and diet.
Keyphrases
- high fat diet
- insulin resistance
- adipose tissue
- nitric oxide
- pulmonary artery
- aortic valve
- high fat diet induced
- binding protein
- pulmonary arterial hypertension
- high glucose
- protein kinase
- metabolic syndrome
- type diabetes
- pulmonary hypertension
- drug induced
- middle aged
- coronary artery
- single molecule
- endothelial cells
- stress induced