Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells.

Songbo ZhaoChunhua WangPing LuYalin LouHuimin LiuTing WangShanshan YangZiyou BaoLin HanXiaohong LiangChunhong MaLifen Gao

Published in: Journal for immunotherapy of cancer (2022)

Overall, the T3/28 chimera significantly prolonged the persistence of CAR-T cells, and T3/28 CAR-T cells possessed potent antitumor activity in mice, shedding new light on potential improvements in adoptive T cell therapies.

Keyphrases

induced apoptosis
cell cycle arrest
cell therapy
stem cells
cell death
signaling pathway
human health
risk assessment
oxidative stress
metabolic syndrome
adipose tissue
binding protein
insulin resistance
climate change