Role of polycyclic aromatic hydrocarbons as a co-factor in human papillomavirus-mediated carcinogenesis.
Chuqing ZhangYunjing LuoRugang ZhongPriscilla T Y LawSiaw Shi BoonZigui ChenChi-Hang WongPaul Kay Sheung ChanPublished in: BMC cancer (2019)
Our results indicate that exposure to PAHs can be a key co-factor in HPV-related cancer development. They could act on all three stages, namely initiation, promotion and progression. Further study is needed to unveil the mechanisms by which PAHs interact with HPV to cause malignancy.