Tumor-infiltrating lymphocytes refine outcomes in triple-negative breast cancer treated with anthracycline-free neoadjuvant chemotherapy.

Miguel Martin Rachel Yoder Roberto Salgado Maria Del Monte-Millán Enrique L Álvarez Isabel Echavarría Joshua M Staley Anne P O'Dea Lauren E Nye Shane R Stecklein Coralia Bueno Yolanda Jerez María Cebollero Oscar Bueno José Angel García-Saenz Fernando Moreno Antón Uriel Bohn Henry L Gómez Tatiana Massarrah Qamar J Khan Andrew K Godwin Miguel Martín Priyanka Sharma

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

sTILs density was independent predictor of OS beyond clinicopathologic features and pathologic response in TNBC patients treated with anthracycline-free CbD chemotherapy. Notably, sTILs density stratified outcomes beyond TNM stage and pathologic response. These findings highlight role of sTILs in patient selection/stratification for neo/adjuvant escalation and de-escalation strategies.

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