The activation of mTOR signalling modulates DNA methylation by enhancing DNMT1 translation in hepatocellular carcinoma.
Mengke ChenYi FangMeinong LiangNing ZhangXinyue ZhangLixia XuXuxin RenQingfeng ZhangYufeng ZhouSui PengJun YuJudeng ZengXiao-Xing LiPublished in: Journal of translational medicine (2023)
In addition to some already identified pro-cancer downstream molecules, the activation of mTOR signalling was found to promote DNA methylation by increasing the translation of DNMT1. Furthermore, combined targeting of mTOR and DNMT1 has been demonstrated to have a more effective tumor suppressive function in HCC.