Prognostic Influence of Preoperative Mammographic Breast Density in Operable Invasive Female Breast Cancer.
Ki-Tae HwangA Jung ChuJongjin KimJong Yoon LeeJi Hyun ChangSohee OhYoung A KimJiwoong JungBumjo OhPublished in: Scientific reports (2018)
We aimed to investigate the potential of preoperative mammographic breast density (MBD) as a prognostic factor in breast cancer. Data of 969 patients with primary breast cancer were analyzed. We defined low MBD as fatty or fibroglandular breast, and high MBD as heterogeneously dense or extremely dense breast, respectively. The high MBD group demonstrated a superior overall survival rate compared to the low MBD group (p < 0.001). Favorable prognostic effects of high MBD were observed in subgroups aged >50 years (p < 0.001) and with positive hormone receptor (HRc) and negative human epidermal growth factor receptor 2 (HER2) (p < 0.001). The high MBD group had a higher proportion of patients aged ≤50 years (p < 0.001) and patients with body mass index (BMI) ≤25 kg/m2 (p < 0.001), and a higher proportion of patients who received chemotherapy (p < 0.001). MBD was a significant independent prognostic factor by multivariable analysis (hazard ratio, 0.382; 95% confidence interval, 0.206-0.708). The high MBD group was associated with superior overall survival rates. Preoperative MBD was a strong independent prognostic factor in operable primary invasive female breast cancer, especially in patients with age >50 years and the HRc(+)/HER2(-) subtype. Favorable clinicopathologic features, active treatments, and other factors could contribute to this causality.
Keyphrases
- prognostic factors
- body mass index
- epidermal growth factor receptor
- patients undergoing
- end stage renal disease
- chronic kidney disease
- emergency department
- ejection fraction
- squamous cell carcinoma
- physical activity
- endothelial cells
- tyrosine kinase
- breast cancer risk
- electronic health record
- radiation therapy
- locally advanced
- childhood cancer