A diabetes-associated genetic variant is associated with diastolic dysfunction and cardiovascular disease.

John MolvinAmra JujicPeter M NilssonMargret LeosdottirUlf LindbladBledar DakaLouise BennetLennart RåstamValeriya LyssenkoMartin Magnusson

Published in: ESC heart failure (2019)

The diabetes susceptibility locus HNF1B is associated with prevalent diastolic dysfunction in two independent Swedish cohorts as well as incident cardiovascular disease.

Keyphrases

cardiovascular disease
left ventricular
type diabetes
blood pressure
oxidative stress
cardiovascular events
cardiovascular risk factors
ejection fraction
genome wide
heart failure
nuclear factor
metabolic syndrome
adipose tissue
genome wide association study