Increased Nose-to-Brain Delivery of Melatonin Mediated by Polycaprolactone Nanoparticles for the Treatment of Glioblastoma.

Edilson Ribeiro de Oliveira JuniorThais Leite NascimentoMariana Arraes SalomãoArtur Christian Garcia da SilvaMarize Campos ValadaresEliana Martins Lima

Published in: Pharmaceutical research (2019)

Nanoencapsulation of MLT was crucial for the selective antitumoral activity against U87MG. In vivo evaluation confirmed nose-to-brain delivery of MLT mediated by nanoparticles, highlighting the formulation as a suitable approach to improve glioblastoma therapy.

Keyphrases

resting state
white matter
drug delivery
cerebral ischemia
stem cells
multiple sclerosis
replacement therapy
walled carbon nanotubes
combination therapy