Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction.

Cavin K Ward-CavinessGolareh AghaBrian H ChenLiliane PfeifferRory WilsonPetra WolfChristian GiegerJoel SchwartzPantel S VokonasLifang HouAllan C JustStefania BandinelliDena G HernandezAndrew B SingletonHolger ProkischThomas MeitingerGabi KastenmüllerLuigi FerrucciAndrea A BaccarelliMelanie WaldenbergerAnnette Peters

Published in: Clinical epigenetics (2018)

There are significant changes in DNA methylation after an incident MI. Nine of these CpGs show consistent changes in multiple cohorts, significantly discriminate MI in independent cohorts, and were independent of medication usage. Integration with gene expression and metabolomics data indicates a link between MI-associated epigenetic changes and BCAA metabolism.

Keyphrases

dna methylation
gene expression
genome wide
cardiovascular disease
heart failure
mass spectrometry
healthcare
electronic health record
left ventricular
big data
peripheral blood
artificial intelligence
deep learning