Krebs von den Lungen-6 (KL-6) is a pathophysiological biomarker of early-stage acute hypersensitivity pneumonitis among pigeon fanciers.

Yuan JiStephen J BourkeMark SpearsLouise V WainGavin BoydPhillip P LynchMatthew CunninghamKenneth BoydIona DonnellyNobuoki KohnoCharles McSharry

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)

Raised KL-6 is associated with acute symptoms of early-stage HP, and its correlation with antibody may support therapeutic strategies when HP is suspected. KL-6 may act as a mechanistic biomarker of early pathogenesis by linking lung pathophysiological changes with an endotype of immune hypersensitivity.

Keyphrases

early stage
drug induced
liver failure
respiratory failure
aortic dissection
sentinel lymph node
pulmonary embolism
squamous cell carcinoma
interstitial lung disease
radiation therapy
physical activity
depressive symptoms
systemic sclerosis