Cellular Senescence: The Villain of Metabolic Disease?: Discovery of a distinct senescent cell population in obesity-induced metabolic dysfunction.
Gung LeePublished in: Molecules and cells (2022)
Senescent p21 high cells in epididymal white adipose tissue (eWAT) aggravate metabolic dysfunction in obese animals. In obesity, p21 high cells are specifically accumulated in stromal vascular fraction of eWAT and they have increased expression of inflammatory genes and NFκB signaling pathway. Transplantation of p21 high cells provokes glucose intolerance whereas clearance of p21 high cells by senolytic agents relieves insulin resistance in obese animals.
Keyphrases
- induced apoptosis
- signaling pathway
- adipose tissue
- cell cycle arrest
- oxidative stress
- weight loss
- metabolic syndrome
- type diabetes
- insulin resistance
- pi k akt
- endoplasmic reticulum stress
- cell death
- bone marrow
- epithelial mesenchymal transition
- blood pressure
- body mass index
- gene expression
- diabetic rats
- skeletal muscle
- endothelial cells
- dna methylation
- cell proliferation
- single cell
- drug induced
- genome wide
- nuclear factor
- cell therapy