Antioxidant effects of dexmedetomidine against hydrogen peroxide-induced DNA damage in vitro by alkaline Comet assay
Mustafa Sirri KotanoğluEla KadiogluEsra EmerceÇetin KaymakAyşe ÖzcanHülya BaşarPublished in: Turkish journal of medical sciences (2020)
There is limited data on the protective effects of DEX against oxidative DNA damage. The primary effect might be cytoprotection. The results herein showed that DEX was protective against H2O2-induced in vitro oxidative DNA damage in lymphocyte cell cultures in a dose-dependent manner. DEX might have a potential therapeutic value in the prevention of oxidative DNA damage in patients.
Keyphrases
- dna damage
- hydrogen peroxide
- oxidative stress
- diabetic rats
- dna repair
- high glucose
- end stage renal disease
- nitric oxide
- newly diagnosed
- ejection fraction
- chronic kidney disease
- high throughput
- stem cells
- cell therapy
- machine learning
- patient reported outcomes
- anti inflammatory
- artificial intelligence
- stress induced
- deep learning