STK11/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition.

Piyada SitthideatphaiboonAna Galan-CoboMarcelo Vailati NegrãoXiao QuAlissa PoteeteFahao ZhangDiane D LiuWhitney E LewisHaley N KempJeff LewisWaree RinsurongkawongUma GiriJiun-Kae Jack LeeJianjun ZhangJack A Roth Stephen G Swisher John Victor Heymach

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

These data provide evidence that LKB1 loss is associated with LRR and poor clinical outcomes in patients with NSCLC treated with radiotherapy and that targeting the KEAP1/NRF2 pathway or GLS inhibition are potential approaches to radiosensitize LKB1-deficient tumors.

Keyphrases

small cell lung cancer
early stage
oxidative stress
locally advanced
advanced non small cell lung cancer
radiation therapy
radiation induced
protein protein
electronic health record
squamous cell carcinoma
big data
machine learning
newly diagnosed
drug delivery
deep learning