Coexisting Genomic Alterations in Risk Stratification of KRASG12C-Mutated Non-Small Cell Lung Cancer.

Sarina Z W Heng Regina Hoo Daniel Shao-Weng Tan

Published in: Cancer discovery (2023)

Negrao and colleagues showed that coalterations in three genes-KEAP1, SMARCA4, and CDKN2A- correlated to poor clinical outcomes in patients with KRASG12C-mutated non-small cell lung cancer treated with sotorasib or adagrasib. Their study highlights how pooling high-resolution real-world genomic data with clinical outcomes can potentially facilitate risk-stratified precision therapies. See related article by Negrao et al., p. 1556 (2).

Keyphrases

high resolution
copy number
electronic health record
mass spectrometry
big data
wild type
gene expression
dna methylation
small molecule
artificial intelligence
tandem mass spectrometry