SARS-CoV-2 Vaccine Induced Atypical Immune Responses in Antibody Defects: Everybody Does their Best.

Ane Fernandez SalinasEva Piano MortariSara TerreriConcetta QuintarelliFederica PulvirentiStefano Di CeccaMarika GuercioCinzia MilitoLivia BonanniStefania AuriaLaura RomaggioliGiuseppina CusanoChristian AlbanoSalvatore ZaffinaCarlo Federico PernoGiuseppe SpadaroFranco LocatelliRita CarsettiIsabella Quinti

Published in: Journal of clinical immunology (2021)

In PAD patients, early atypical immune responses after BNT162b2 immunization occurred, possibly by extra-follicular or incomplete germinal center reactions. If these responses to vaccination might result in a partial protection from infection or reinfection is now unknown. Our data suggests that SARS-CoV-2 infection more effectively primes the immune response than the immunization alone, possibly suggesting the need for a third vaccine dose for patients not previously infected.

Keyphrases

immune response
sars cov
end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
patient reported outcomes
electronic health record
oxidative stress
machine learning
deep learning
respiratory syndrome coronavirus
patient reported
diabetic rats
coronavirus disease