SARS-CoV-2 Vaccine Induced Atypical Immune Responses in Antibody Defects: Everybody Does their Best.
Ane Fernandez SalinasEva Piano MortariSara TerreriConcetta QuintarelliFederica PulvirentiStefano Di CeccaMarika GuercioCinzia MilitoLivia BonanniStefania AuriaLaura RomaggioliGiuseppina CusanoChristian AlbanoSalvatore ZaffinaCarlo Federico PernoGiuseppe SpadaroFranco LocatelliRita CarsettiIsabella QuintiPublished in: Journal of clinical immunology (2021)
In PAD patients, early atypical immune responses after BNT162b2 immunization occurred, possibly by extra-follicular or incomplete germinal center reactions. If these responses to vaccination might result in a partial protection from infection or reinfection is now unknown. Our data suggests that SARS-CoV-2 infection more effectively primes the immune response than the immunization alone, possibly suggesting the need for a third vaccine dose for patients not previously infected.