Hippocampal epileptogenesis in autoimmune encephalitis.
Michele RomoliParaskevi KrashiaArjune SenDiego FranciottaMatteo GastaldiAnnalisa NobiliAndrea ManciniElena Nardi CesariniPasquale NigroNicola TambascoNicola Biagio MercuriLucilla ParnettiMassimiliano Di FilippoMarcello D'AmelioSarosh R IraniCinzia CostaPaolo CalabresiPublished in: Annals of clinical and translational neurology (2019)
Using patient CSF, we have demonstrated that the AE-associated antibodies against LGI1 and CASPR2 are able to increase hippocampal CA1 neuron excitability, facilitating epileptiform activity. These findings provide in vivo pathogenic insights into neuronal dysfunction in these conditions.