Nrf2-Heme Oxygenase-1 Attenuates High-Glucose-Induced Epithelial-to-Mesenchymal Transition of Renal Tubule Cells by Inhibiting ROS-Mediated PI3K/Akt/GSK-3β Signaling.

Jong Ho ShinKyeong Min KimJin Uk JeongJae Min ShinJu Hyung KangKitae Bang Joo-Heon Kim

Published in: Journal of diabetes research (2019)

The present study suggests that Nrf2-HO-1 signaling has an inhibitory role in the regulation of EMT through the modulation of ROS-mediated PI3K/Akt/GSK-3β activity, highlighting Nrf2-HO-1 and GSK-3β as potential therapeutic targets in diabetic nephropathy.

Keyphrases

pi k akt
high glucose
cell cycle arrest
signaling pathway
induced apoptosis
diabetic nephropathy
endothelial cells
oxidative stress
epithelial mesenchymal transition
cell proliferation
dna damage
cell death
reactive oxygen species
diabetic rats
climate change