Melatonin attenuates prostatic inflammation and pelvic pain via Sirt1-dependent inhibition of the NLRP3 inflammasome in an EAP mouse model.
Jing ChenLi-Gang ZhangHe-Xi DuChang-Sheng ZhanYi LiuMeng ZhangXian-Guo ChenLong-Ping WenLi ZhangChao-Zhao LiangPublished in: The Prostate (2021)
The results indicated that melatonin could attenuate prostate inflammation and pelvic pain by inhibiting the NLRP3 inflammasomes signaling pathway through the activation of Sirt1 in mice with EAP, and these efforts should provide a promising therapeutic strategy for CP/CPPS.
Keyphrases
- nlrp inflammasome
- oxidative stress
- signaling pathway
- chronic pain
- mouse model
- pain management
- neuropathic pain
- benign prostatic hyperplasia
- prostate cancer
- rectal cancer
- ischemia reperfusion injury
- pi k akt
- induced apoptosis
- epithelial mesenchymal transition
- radical prostatectomy
- type diabetes
- spinal cord injury
- quality improvement
- spinal cord
- insulin resistance
- skeletal muscle
- cell proliferation