Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock.
Margaret R PassmoreLiam ByrneNchafatso G ObonyoLouise E See HoeAi-Ching BoonSara D DiabKimble R DunsterKavita BishtJohn-Paul TungMohd H FauziMonica NarulaSanne E PedersenArlanna Esguerra-LallenGabriela SimonovaAnnette SultanaChris M AnsteyKiran ShekarKathryn MaitlandJacky Y SuenJohn F FraserPublished in: Respiratory research (2018)
This data shows that the inflammatory response is enhanced when a host with endotoxemia is resuscitated with saline, with a comparatively higher release of inflammatory cytokines and endothelial/glycocalyx damage, but no change in matrix metalloproteinase levels.