The Essential Role of Peptidylarginine Deiminases 2 for Cytokines Secretion, Apoptosis, and Cell Adhesion in Macrophage.

Hui-Chun YuChien-Hsueh TungKuang-Yung HuangHsien-Bin HuangMing-Chi Lu

Published in: International journal of molecular sciences (2020)

This study showed that PADI2 could promote IL-1β, IL-6, and TNF-α production in macrophages, promote macrophage apoptosis through caspase-3, caspase-2, and caspase-9 activation and enhance cell adhesion via FAK, paxillin, and PAK1. Therefore, targeting PADI2 could be used as a novel strategy for controlling inflammation caused by macrophages.

Keyphrases

cell adhesion
cell death
induced apoptosis
oxidative stress
cell cycle arrest
endoplasmic reticulum stress
adipose tissue
rheumatoid arthritis
cancer therapy
signaling pathway
cell migration