Gastric inhibitory polypeptide receptor antagonism suppresses intramuscular adipose tissue accumulation and ameliorates sarcopenia.

Yuya TakahashiHiroki FujitaYusuke SeinoSatoko HattoriShihomi HidakaTsuyoshi MiyakawaAtsushi SuzukiHironori WakiDaisuke YabeYutaka SeinoYuichiro Yamada

Published in: Journal of cachexia, sarcopenia and muscle (2023)

GIP promotes the differentiation of muscle FAPs into adipocytes and its receptor antagonism suppresses IMAT accumulation and promotes muscle regeneration. Pharmacological GIP receptor antagonism may serve as a novel therapeutic approach for sarcopenia.

Keyphrases

adipose tissue
skeletal muscle
stem cells
insulin resistance
high fat diet
type diabetes
binding protein
metabolic syndrome
wound healing
high fat diet induced