Smart Dual-Sensor Wound Dressing for Monitoring Cutaneous Wounds.

Managing slow healing wounds and associated complications are challenging, time-consuming, and expensive. Systematic collection, analysis, and dissemination of correct wound status data is critical for enhancing healing outcomes and reducing complications. However, traditional data collection approaches are often neither accurate nor user-friendly, require diverse skill levels, and the resulting data is frequently inconsistent and unreliable. Here, we describe a hydrogel-based smart wound dressing which with integrated pH and glucose sensors for continuous wound monitoring. In the current study, growth factor delivery modules and an array of colorimetric glucose sensors were incorporated into the dressing to promote wound healing and extend the dressing's utility for diabetic wound treatment. Furthermore, the efficacy of the wound dressing in monitoring infection and supporting wound healing via antibiotic and growth factor delivery was investigated in mice models. The updated dressing revealed excellent healing benefits on non-infected and infected wounds, as well as real-time monitoring and early detection of wound infection. This article is protected by copyright. All rights reserved.